This paper explores integrating self-tuning updates and sequential consistency to enable transparent replication of large-scale information dissemination services. We focus our attention on information dissemination services, a class of service where updates occur at an origin server and reads occur at a number of replicas, and our data replication system supports transparent replication by providing two crucial properties: (1) sequential consistency to avoid introducing anomalous behavior to increasingly complex services and (2) self-tuning transmission of updates to maximize performance and availability given available system resources. We meet these aggressive consistency and self-tuning goals using a novel architecture that (1) pushes invalidations on reliable FIFO network channels, (2) pushes updates on unreliable, priority-ordered, low-priority network channels, and (3) carefully schedules the application of invalidations and updates at each replica. Our analysis of simulations and our evaluation of a prototype implementation support the hypothesis that it is feasible to provide transparent replication for information dissemination applications. For example, in simulations our system’s performance is a factor of three to four faster than a demandbased system for a wide range of configurations.