David Bruton, Jr. Centennial Professor in Computer Science
Department of Computer Science
The Center for Computational Biology and Bioinformatics
The University of Texas at Austin
My research combines mathematics, computer science, probability, and statistics, in order to develop algorithms with improved accuracy for large-scale and complex estimation problems in phylogenomics and metagenomics. My major interests include multiple sequence alignment and phylogeny estimation (both gene trees and species trees) and metagenomic analysis, but I also work in Historical Linguistics. My current work aims to develop methods for ultra-large datasets (anywhere from 10,000 to 1,000,000 sequences), including datasets that are highly fragmentary and present other real world challenges. We use real data and perform massive simulations to evaluate the performance of methods that we develop, and also collaborate closely with biologists and linguists in data analysis. I will be moving to the University of Illinois at Urbana-Champaign in Fall 2014, and will be a Professor in Bioengineering, and in Computer Science, and also in Mathematics.
My current research is funded by the National Science Foundation (DEB 0733029 and DBI-1062335). I also recently benefited from support of the John P. Simon Guggenheim Foundation, and early support from the David and Lucile Packard Foundation, the Radcliffe Institute for Advanced Study at Harvard University, and the Program for Evolutionary Dynamics at Harvard University.
2014 PhyloLab Conference on Computational Biology, at the University of Texas at Austin on May 31, 2014, describing new methods in metagenomics, phylogenomics, and comparative genomics.
Mathematical, Statistical and Computational Aspects of the new science of Metagenomics, 24 March to 17 April, 2014, at the Sir Isaac Newton Institute for Mathematical Sciences at Cambridge University, UK.
Phylogenomics Symposium and Software School on June 19 and 20, 2014, co-located with the Evolution 2014 meeting.
Summer School for Big Data in Biology course on advanced methods in multiple sequence alignment, gene tree estimation, species tree and phylogenetic network estimation from multiple (potentially conflicting) gene trees, and metagenomics, May 19-22, 2014 (at UT-Austin).
"Plus de détails, plus de détails, disait-il à son fils, il n'y a d'originalité et de vérité que dans les détails..." -- Stendhal, Lucien Leuwen (a quote much loved by my stepfather, Martin J. Klein, and an essential guide for all scholarship).
Click here for Google Scholar Citations (i10-index 99 and h-index 45).
The CIPRES Project is finally over, but the CIPRES Portal is still available through the TeraGrid (see also the CIPRES Science Gateway story). Here is an abridged version of the CIPRES final report.
Siavash Mirarab, my PhD student, has been awarded a fellowship by the Howard Hughes Medical Institute.