Chandrajit Bajaj


We are developing tools that will allow exploration of the functional consequences of variation in dendritic structure and composition on signaling in dendrites at a finer scale. Over time, we will systematically upscale these models as we learn how to simplify the realistic domain structures appropriately and allow incorporation of those features that significantly impact dendritic signaling into more realistic whole neuronal models.


models2We are creating models based on the Poisson-Nernst-Planck equations (show below) for use on models at the scale of realistic domains as shown in the pipeline.







We will examine the effects that various spine parameters (neck width, neck length, base-to-tip length, etc) have on the results of our simulations.



We will also model electrical field effects which is an important feature in many brain regions, including the hippocampus. These effects include synchronous bursting behavior which is known to correlate with epileptic seizures.