PhyloLab Whole Genome Page

Phylogeny Reconstruction from Gene Order Data

The genomes of some organisms have a single chromosome or contain single-chromosome organelles (such as mitochondria or chloroplasts) whose evolution is largely independent of the evolution of the nuclear genome for these organisms.  Many single-chromosome organisms and organelles have circular chromosomes. Given a particular strand from a single chromosome, whether linear or circular, we can infer the ordering of the genes, along with directionality of the genes, thus representing each chromosome by an ordering (linear or circular) of signed genes. Note that picking the complementary strand produces a different ordering, in which the genes appear in the reverse direction and reverse order. The evolutionary process that operates on the chromosome can thus be seen as a transformation of signed orderings of genes.

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